Nattokinase (NK for short), also known as subtilisin, is a serine protease produced by Bacillus subtilisl natto during the natto fermentation. It has the functions of dissolving thrombus, reducing blood viscosity, improving blood circulation, softening and increasing blood vessel elasticity.
It was discovered in natto in 1980. It is composed of 275 amino acids in a fixed arrangement and has a molecular weight of 27,724. It has the unique function of breaking down thrombus. The active effect is expressed by the inherent unit FU.
How nattokinase break down blood clot:
nattokinase stimulates vascular endothelial cells to produce tissue-type plasminogen activator (t-PA), t-PA activates plasminogen to plasmin, dissolving fibrin, Directly dissolve blood clot; at the same time, urokinase in the human body is activated to urokinase, and urokinase and t-PA activate plasminogen together to dissolve fibrin.
Compared with other thrombolytic drugs, nattokinase has low cost, good safety, small molecular weight, good oral effect, high thrombolytic activity, and long duration of action. It is expected to be developed as a new type of thrombolytic agent with strong market competitiveness.
The international standard unit of nattokinase is "FU", which refers to the content of nattokinase per nattokinase product; "FU/g" refers to the content of nattokinase per gram of raw natto, and both exist the difference.
It is not recommended for pregnant women and should be suspended for 2 weeks before and after surgery to avoid affecting wound healing.
For other diseases related to blood coagulation, you must consult a doctor before eating.
If there is a lot of bleeding, such as rupture of blood vessels, accidents, etc., it should also be avoided.
For example, patients with cerebral hemorrhage must be suitable for consumption 3 months after the onset of symptoms.
Nattokinase is a functional food and cannot replace drugs.
It can be absorbed directly into the small intestine, and the action time in the body is 8-12 hours.
Low-calorie, low-protein, obese and kidney disease patients can eat with peace of mind.
It is not inconsistent with the medicine and can reduce the adverse reactions of the medicine.
1. The daily intake of 2000FU is the amount to prevent cardiovascular and cerebrovascular diseases for normal or sub-healthy people. Most people react after taking it for about 7 days, feel energetic, and the symptoms of dry eyes begin to improve.
2. The daily intake of 2000FU-5000FU is the recommended dosage for patients with cardiovascular and cerebrovascular diseases. After 15 days, most of the body has positive reactions, such as cold hands and feet, chest tightness, palpitation, limb numbness, dizziness, insomnia and other symptoms gradually relieved, 2-3 months later, The blood pressure and blood lipid indexes gradually turn to normal. When the indexes are normal, the amount can be reduced to the healthy care dose.