Melatonin (MT) is one of the hormones secreted by the pineal gland. Melatonin belongs to the indole heterocyclic compound, and its chemical name is N-acetyl-5 methoxytryptamine, also known as pinealin, melatonin, and melatonin. After the synthesis of melatonin, it is stored in the pineal gland, and the sympathetic nerve excites the pineal gland cells to release melatonin. The secretion of melatonin has an obvious circadian rhythm, the secretion is inhibited during the day, and the secretion is active at night. Melatonin can inhibit the hypothalamic-pituitary-gonad axis, and reduce the contents of gonadotropin-releasing hormone, gonadotropin, luteinizing hormone and follicular estrogen, and can directly act on the gonads, reducing androgens, estrogen and The content of progesterone. In addition, MT has strong neuroendocrine immunomodulatory activity and free radical scavenging antioxidant capacity, which may become a new antiviral treatment method and approach. MT is finally metabolized in the liver, and damage to liver cells can affect the level of MT in the body.
Chemical formula: C13H16N2O2
Molecular weight :232.28
CAS Registry Number :73-31-4
Melt point :116 to 118 ℃
Boiling point :374.44 ℃ (760mm
External view: white crystalline powder
Flash point : 231.9 ℃
Security description: S24/25
Hazard symbol :R60
For example, in pyridine, 5-methoxytryptamine is treated with acetic anhydride at room temperature to obtain N,N-diacylated derivatives, which are then converted in lye, and the yield can reach 80%.
Melatonin is a hormone in the body that induces natural sleep. It overcomes sleep disorders and improves sleep quality by regulating people's natural sleep. The biggest difference between it and other sleeping pills is that melatonin is not addictive and has no obvious side effects. Oral 1-2 tablets (about 1.5-3 mg of melatonin) before going to bed at night, usually within 20 to 30 minutes, you can feel drowsiness, and melatonin automatically loses its efficacy after dawn in the morning, and you will not be tired or awake after getting up.
①LD50>10g/kg (large, mouse, oral).
②Ames test, mouse micronucleus test, and mouse sperm aberration test are all negative.
③It is an endogenous substance, so it is not a foreign body to the body, has its own metabolic pathway in the body, and will not cause accumulation in the body. The biological half-life is short, and it drops to the physiological level of normal people after 7-8 hours of oral administration. After more than 3000 people oral test (a few grams, that is, thousands of times the normal dose, which lasted 1 month), no abnormalities were found.
④Not suitable for people and precautions: It is not suitable for adolescents, pregnant women and lactating women, patients with autoimmune diseases and depressive mental illnesses. Not to be taken for driving, before or during mechanical work, and those engaged in dangerous work