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Do you know St. John's wort

Nov 03, 2021

What is Hypericum perforatum?

Hypericum perforatum is called St. John's wort. The St. John’s Wort name comesfrom the fact that the plant usually blooms around June 24 , which is the birthday of St. John, the Baptist in the Bible. At the same time, people thought the blood juice in the plant just like the blood flowing from St. John’s. People in the Middle Ages believed that St. John's wort had a healing effect and could drive away demons.

The whole plant is of medicinal value. Traditional Chinese medicine literature rarely describes the medicinal use of this herb in detail. However, there are more than 110 articles on the use of Hypericum perforatum in the treatment of depression in foreign countries. In Germany, 40% of all depression medications use this herb. After dozens of scientific-based studies, Hypericum perforatum’s performance is backed up by intensive medical research and evidence.

St. Johns Wort

General benefits

This roadside weed contains 10% tannins and Hypericin, Pseudo-Homosilicin, Hypericum Perforatum Resin Aminoaniline and many active ingredients. For a long time, many people believe that the hypericin in Hypericum perforatum is an effective ingredient in the treatment of depression. In addition, traditional medical literature records that it has antibacterial, hemostatic, antipyretic, burn, traumatic and other therapeutic effects. It is a folk herb familiar to many people. Modern medical research knows that carotenoids contained in herbal medicines can heal burns, and xanthones have antiviral effects.

A report on Hypericum perforatum published in Europe last year showed that it can relieve the psychophysiological symptoms of amenorrhea, such as restlessness, depression, anxiety, inattention, mental tension, etc.


Take Hypericum perforatum and a teaspoon of herbs, add water toboil, or take medicines and juices extracted from alcohol.

However, Hypericum perforatum also has certain side effects such as abdominal pain, sensitivity to sunlight, dizziness, mania and moodchanges. Avoid taking Hypericum perforatum at the same time withcertain drugs ,such as cyclosporine, theophylline and coumarin to avoid drug interactions and compromise, let alone taking the drugs yourself.



St. John's wort extract is an antidepressant commonly used for its neurological effects. Through the active ingredient hypericin, it is effective as a dopamine-related antidepressant.

A single high-dose administration of Hypericum perforatum (300mg/kg 0.3% hypericin and 4.1% perferrin) in normal rats seems to increase the extracellular dopamine in the prefrontal cortex by 40% after one hour.

When St. John's wort is compared with tricyclic antidepressants (TCA) and SSRIs, the benefits of St. John's wort extract are 1.02 and 1.00, respectively; this shows that there is no real difference between the drug and St. John's wort. In addition, the dropout rate (dropouts) associated with St. John's wort juice was significantly lower than the two TCAs (OR 0.24) and SSRIs (OR 0.53), which indicates that St. John's wort has less side effects.

A study compare the performance of Hypericum perforatum and Imiramine, a Tricyclic antidepressants. It shows that the effects of the two are similar, but patients are more willing to accept Hypericum perforatum. Among them, 26% of patients gave up taking the drug after taking imipramine while only 3% patients of Hypericum perforatum group gave up.