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Huperria serrata extract

Huperria serrata extract

Latin Name: Huperziaserrata(Thunb.)Trev.
Part Used: whole herb
Specification: 1%-98% Huperzine A
Grade:Food, Health Care Products
Package:1kg/Bag, 25kg/Drum

Description

Product Introduction

Huperria serrata extract is a product extracted from Melaleuca and dried whole plants as raw materials. Commercially labeled extracts are usually standardized to contain 1% Huperzine A.

The folk use its whole herb to treat carbuncle swollen poison, snake bites, burns and scalds. Huperzine A, the alkaloid component in the dry-bed tower, is a potent and reversible cholinesterase inhibitor, which can improve the functional decline of senile memory, and can significantly improve the memory, cognition and behavior of patients with Alzheimer's disease Ability is a promising drug for the treatment of Alzheimer's disease. Synthetic Huperzine A is available too.


Product Character

Plant source: Huperzia serrata

Product Appearance:Brown to white powder

Active Ingredient:Huperzine A

Specifications: Huperzine A 1%--99%

Molecular Weight: 242.32

Molecular formula: C15H18N2O

Storage: Low temperature storage (no more than 20 ℃)


Pharmacology

Huperzine A is a cholinesterase inhibitor, which selective inhibitory affect on true ChE and and is easy to pass through the blood-brain barrier. Extracted Huperzine A can promoe memory reproduction and enhancing memory retention.

PHYSICAL / CHEMICAL/ MICROBIOLOGICAL

APPEARANCE

Fine powder

COLOR

Brown

TASTE & ODOR

Characteristic

PARTICLE SIZE

100% pass 80 mesh or customized 200mesh

MOISTURE (%)

≤ 5%

ASH (%)

≤ 5%

HEAVY METAL

Total <10PPM

Pb<2PPM

As<2PPM

Cd<2PPM

Hg<0.5PPM

MICROBIOLOGICAL

TPC (CFU/GM)

<1,000 cfu/g

MOULD & YEAST

< 100cfu/g

E.COLI

Negative

PATHOGENIC BACTERIA

STAPHYLOCOCCUS

Negative

SALMONELLA

Negative

LISTERIA MONOCYTOGENES

Negative

STORAGE

Cool, Ventilate & Dry

PACKAGE

25kgs/drum

SHELF LIFE

24Months

REMARK

Customized specification also can be achieved

Production process

The Huperria serrata herb are percolated with 1-1.5% hydrochloric acid, adjusted the solution to pH 6. Flow the fluid through macroporous resin to get selected solution, washed with water and eluted with 50% ethanol, then concentrate, dried, and pulverize into powder. Dilute with ethanol, concentration the solution then dry and crush. Finally, Huperria serrata extract is done.


Function

1.Huperzine A is a highly selective anticholinesterase inhibitor that can significantly promote cholinergic transmission at nerve junctions

2. Huperzine A was used in the early treatment of myasthenia gravis. Modern pharmacological studies have shown that Huperzine A is a good medicine to cure Alzheimer's disease (senile memory impairment).


Prospect

It is reported that there are more than one million people with Alzheimer’s disease or AD in the United States, and 25% of Alzheimer’s patients in Japan. A survey report in Shanghai shows that 4.5% of people over 55 in the area suffer from severe dementia and 14.4% have mild dementia. Dementia, so the market prospects of Melaleuca extract and related products are prospective.


Contraindications

Patients with epilepsy, renal insufficiency, mechanical intestinal obstruction, urinary tract obstruction, angina pectoris, bradycardia and bronchial asthma shall not use.







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