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Do You Know Hesperidin And Diosmin

Mar 23, 2021

Introduction

Diosmin is a natural flavonoid intravenous affinity drug. This drug can quickly relieve the symptoms of acute hemorrhoids. For chronic hemorrhoids patients, it can relieve symptoms, prevent the recurrence of acute hemorrhoids, and significantly reduce the postoperative hemorrhoids Bleeding. It can also be used for chronic venous insufficiency, such as varicose veins and leg ulcers.

Since the content of diosmin in natural plants is very low, the current medicinal diosmin is chemically synthesized from the natural extracted ingredient hesperidin.

hesperidin & diosmin

  

How is diosmin is made from hesperidin 

Add a high-boiling solvent to the corticoside, distill under reduced pressure to remove the crystal water in the hesperidin, and then add a reaction solvent that is 3-20 times the weight of hesperidin, and the weight is 0.3-0.6 times the weight of hesperidin Iodine, react at 80-120℃ for 8-20 hours, concentrate under reduced pressure, add alkaline aqueous solution, hydrolyze at 30-80℃ for 1-8 hours, adjust pH to acidity with dilute acid, and filter to obtain The solid product is washed with water until it is neutral and dried to obtain diosmin. The dilute acid can be dilute hydrochloric acid, dilute sulfuric acid or dilute acetic acid, etc., and the pH value is 3-6.

The above-mentioned high boiling point solvent is dimethylformamide, dimethylacetamide, pyridine, morpholine or piperidine, while the reaction solvent is pyridine or dimethylformamide, and the alkaline aqueous solution is sodium hydroxide, hydroxide One of potassium, sodium carbonate or potassium carbonate solution.

Diosmin is made from hesperidin, both of which come from citrus plants and belong to flavonoids. Pharmaceutical factories often combine hesperidin and diosmin as a tropic drug formulation, which means that this substance is good for the structure of blood vessels. Some companies convert part of hesperidin to diosmin and sell a combination product containing 90% diosmin and 10% hesperidin. Although this formula needs to be obtained by prescription in some European countries, diosmin and hesperidin are sold in the market in the form of tonic health products elsewhere.

 Pharmaceutical function

Studies have confirmed that diosmin and hesperidin can interfere with arachidonic acid metabolism and histamine release. This flavonoid also inhibits thromboxane and prostaglandin activation. These activities prevent inflammatory reactions and are therefore believed by some to reduce allergic reactions. Doctors often recommend diosmin and hesperidin to patients with hemorrhoids. Patients taking this combination formula feel pain, swelling and itching significantly reduced.

diosmin can improve vessel extension

 

A study aimed at increasing the sensitivity of cells to calcium by diosmin confirmed that vascular tone was improved. Some research results have led doctors to believe that part of the cause of venous insufficiency and valve failure is related to inflammatory diseases. This herbal derivative can be used to treat varicose veins. In addition to its anti-inflammatory effects, the benefits of diosmin include protecting blood vessels by preventing cells from adhering to the lining of blood vessels, promoting blood circulation and reducing endothelial damage. Some doctors also use diosmin and hesperidin to treat vascular insufficiency and venous stasis.

 

Comsuption tips

 

The doctor claimed that the blood circulation effect of diosmin and hesperidin could increase the recovery rate of venous stasis ulcers. Medical staff also use this mixed formula to promote lymphedema and blood circulation in patients undergoing secondary breast cancer surgery. Some studies have confirmed that Diosmin also has the effect of scavenging free radicals, so it can provide antioxidant activity.

 

Doctors usually treat diosmin and hesperidin for no more than six months. Patients with hemorrhoids take 1500 mg at the beginning, 2-3 times a day for 4 days. Then take 1000 mg twice a day for the next 3 days. The next two months is 500 mg twice a day, which can prevent hemorrhoids from recurring. People with blood circulation diseases should follow the doctor's recommended dosage for 2-6 months.

 

Like any health products, it is also recommended to consult a doctor before using diosmin and hesperidin. Some people is likely to experience abdominal discomfort, diarrhea, and headaches. Doctors do not recommend taking herbal supplements with anticoagulants (such as aspirin and warfarin) because diosmin and hesperidin can increase the effects of these drugs. In addition, bioflavonoids can also interfere with the activity of calcium channel blockers, and it is not recommended to take herbal health products together with tamoxifen.