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What is Sodium hyaluronate

May 10, 2021

On January 8, sodium hyaluronate is approved as novel foods ingredient by China National Health Commission . As an important oral cosmetic ingredient alongside collagen, sodium hyaluronate will undoubtedly inject a new force into my country's functional food industry.

Hyaluronic acid&sodium hyaluronate

Hyaluronic acid is an acidic mucopolysaccharide widely distributed in various parts of the human body. It has a variety of important physiological functions, such as skin retention, lubricating joints, regulating the permeability of blood vessel walls, regulating protein, and promoting wound healing. Sodium Hyaluronate (SODIUM HYALURONATE) is produced by fermentation of Streptococcus equi subsp. zooepidemics based on glucose, yeast powder, peptone, etc., and is a linear macromolecular polysaccharide. The functions of the two are similar, the difference is that hyaluronic acid is an kind of acid, and sodium hyaluronate is salt. Sodium-containing sodium hyaluronate is more stable and has a smaller molecule, which can be absorbed more effectively and penetrate deep into the skin.

sodium hyaluronate

The benefit of sodium hyaluronate on the skin is mainly are in three aspects:

Moisture: Moisturizing is the most important role of sodium hyaluronate. Sodium hyaluronate has super water absorption capacity, which can absorb 1000 times of its own volume of water to form an elastic viscous matrix to fill in the voids of the tissue It is a natural water-retaining agent for the skin.

Nutrition : Sodium hyaluronate is a substance inherent to the skin, and exogenous sodium hyaluronate is an endogenous supplement to the skin. Small molecules of sodium hyaluronate can penetrate into the epidermis of the skin to promote the supply of skin nutrition and The excretion of waste can prevent skin aging and play a certain anti-wrinkle effect.

Repairing effect: Sodium hyaluronate can promote the repair of skin damage. It can accelerate the regeneration of epidermal cells by promoting the proliferation and differentiation of epidermal cells, promote the healing of the damaged skin, and also have a certain effect on burns caused by ultraviolet rays.

In addition, sodium hyaluronate is also an important component of articular cartilage. Oral sodium hyaluronate can effectively relieve the symptoms of arthritis and protect joint function. Appropriate intake of hyaluronic acid can reduce the content of bone resorption markers pyridine and deoxypyridine to normal levels and improve bone density.

Initially, the development of sodium hyaluronate was mainly based on cosmetics, eye drops, and bone and joint injections. Now, sodium hyaluronate appears as an important cosmetic skin care ingredient in oral cosmetic products. Studies have shown that oral sodium hyaluronate is also effective. Within 2 hours after consuming hyaluronic acid, the amount of hyaluronic acid in the body reaches its peak. With the consumption of hyaluronic acid, the body content will decrease in 2-4 hours. However, after 4 hours, after digestion, the concentration of hyaluronic acid synthetic raw materials in the body rises, thereby increasing the acceleration of hyaluronic acid synthesis, and hyaluronic acid peak appears again.

Sodium Hyaluronate application

Oral beauty market and sodium hyaluronate

According to Innova data, the global average compound annual growth rate of new food, beverage and dietary supplement products with skin health claims from 2017 to 2019 is as high as 58%. Among them, millennials and Generation Z prefer to use functional foods and beverages to achieve beauty .Innova also found that the application of a new generation of beauty ingredients has begun to surpass traditional beauty ingredients such as vitamin C and vitamin E. For example, hyaluronic acid is the key ingredient with the highest growth rate in the release of new food, beverages and dietary supplements with skin health claims. The compound annual growth rate in the past 5 years is as high as 59%.

In May 2008, sodium hyaluronate was approved as a new resource food in my country for use as a health food raw material. At present, foods containing sodium hyaluronate in my country are mainly health foods, whose main functions are to improve skin moisture and increase bone density. At present, a total of 25 products have been approved.

Although there are few related products, domestic consumers still have a high degree of awareness of hyaluronic acid. The Chinese Nutrition and Health Food Branch of the Chinese Nutrition Society and the Dermatologist Branch of the Chinese Medical Doctor Association jointly issued the "2020 China Beauty Nutrition White Paper" "In the survey of ingredients related to skin elasticity and moisture, the vast majority of respondents believe that collagen has the greatest relationship with skin elasticity, followed by moisture, hyaluronic acid, elastin, lipids, vitamins and minerals.


After incorporating sodium hyaluronate into the new food raw material, the scope of use can be expanded to milk and dairy products, beverages, alcohol, cocoa products, chocolate and chocolate products (including cocoa butter substitute chocolate and products), as well as sweets and frozen drinks , The recommended consumption is less than or equal to 200 mg/day, and it is not suitable for infants, pregnant women and breastfeeding women. The mainstream food and beverage applications of sodium hyaluronate have basically been covered, and a large number of new product applications are expected to appear in the next 1-2 years.

Common application combinations with sodium hyaluronate

1. Sodium Hyaluronate + Collagen

Most oral beauty products add hyaluronic acid and collagen at the same time, both of which are important components of skin and articular cartilage. Sodium hyaluronate is mainly used for skin moisturizing and moisturizing, while collagen is mainly used to increase skin elasticity and anti-aging. The combination can achieve the effect of 1+1>2.

2. Sodium Hyaluronate + Astaxanthin

As one of the strongest antioxidants in nature, astaxanthin's strong antioxidant properties make it a potential photoprotective agent, which can remove free radicals that cause skin aging, protect cell membranes and mitochondrial membranes from oxidative damage, and prevent skin Light aging. Sodium hyaluronate also has a certain repairing effect on skin damage caused by ultraviolet rays. The combination of the two is often used in beauty products that protect the skin from ultraviolet rays and help the skin to lock water.

3. Sodium Hyaluronate + GABA/L-Theanine

Emotional sleep is also a hot topic in recent years. Sodium hyaluronate also often appears in sleep-related products. It is used in conjunction with GABA, L-theanine, and melatonin to make beauty sleep more effective.

4. Sodium Hyaluronate + Glucosamine Chondroitin

Sodium hyaluronate is not only the skin, but also the main component of joint synovial fluid. It is secreted by synovial cells, fibroblasts and chondrocytes. It has various physiological functions such as regulating protein expression, assisting the diffusion and transport of water and electrolytes, and promoting wound healing. It plays an important role in the protection of articular cartilage. It is often used in combination with glycochondroitin to relieve joint inflammation and pain.

Compared with collagen, sodium hyaluronate is not only colorless and tasteless, but also easily soluble in water without changing the original properties of the product. Therefore, it has a stronger advantage in food and beverage applications and can be easily added to various applications. It can be seen that sodium hyaluronate is very likely to become the next hot new food material.