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D-mannose, Cranberry Extract , Bearberry Leaf Extract for Urinary Tract Infection

Nov 04, 2022

Generally speaking, the most effective treatment for urinary tract infection is antibiotics combined with proprietary Chinese medicines to improve symptoms through sterilization and anti-inflammatory. However, there are several disadvantages of this treatment method:

1. Injury to the human liver, kidney and intestine: Most antibiotics are metabolized by the liver and kidneys, and are irritating to the intestine to a certain extent. Long-term abuse probes to cause damage to the liver, kidneys, and intestines. Generally speaking, the continuous use of antibiotics should not exceed 14 days;

2. The symptoms are repeated: long-term use of antibiotics is probably to generate resistant bacteria. At the same time, the biofilm of bacteria will continuously release fungi or bacteria, causing repeated infections;

3. Destroy the flora: The broad-spectrum sterilization of antibiotics targets not only the bad bacteria in the body, but also the good bacteria in the body, which can easily imbalance. Especially for women, long-term use of antibiotics or abuse of lotion can easily cause fungal vaginitis.

4.Potential risk to special groups: children, the elderly, especially pregnant women. Some antibiotics are contraindicated due to drug side effects (and the potential for adverse effects on the fetus), and pregnancy is a time of high incidence of urinary tract infections.

D-mannose-helps cure UTI


D Mannose is a relatively common ingredient used in the treatment of urinary tract infections, UTI in short in foreign countries. Since the 1980s, doctors abroad have used D-mannose to treat urinary tract infections.

D-Mannose has a strong adsorption effect on the bacteria in the urinary tract system. When passing through the kidneys, bladder and urethra, D-Mannose will encapsulate the pathogenic bacteria that sticks to the urinary tract system, excreted with the urine. Meanwhile, D-mannose is a monosaccharide that occurs in natural foods. Mannose does not participate in metabolism after intake, so D mannose does not fluctuate blood sugar. 90% of the ingested D mannose will be excreted intact through the urethra within 30-60 minutes, and 99% of the residual content will be excreted in the next 8 hours, the metabolism is very safe and complete.

In addition, there is a very important advantage that D-Mannose can destroy the bacterial biofilm, and biofilm is one of the important elements of repeated urinary tract infections. Bacterial biofilm is the protective film of bacteria and fungi, which can prevent probiotics, antibiotics, and plant active ingredients from directly contacting the bacteria and fungi. After taking D-Mannose for 15 days, the QoL index of urinary tract infection symptoms such as dysuria, frequent urination, urgency, feeling of falling, pubic pain, low back pain, hematuria, and nocturia decreased significantly.

2)bearberry leaves

bearberry leaf

In traditional medical practice, bearberry leaves have been used for centuries to treat urinary tract infections. Current modern findings support the claim that bearberry leaves can treat urinary tract infections, as several compounds present in this plant exhibit potent antibacterial properties. The most important active ingredient is Arbutin

Arbutin, also known as arbutin, has antibacterial properties and is a mild diuretic that can be used to treat diseases of the urinary tract system, including cystitis and urinary tract stones. Arbutin has a wide range of application scenarios. In addition to antibacterial and diuretic, it is more used as a whitening ingredient in some cosmetics.

Bearberry leaf and its extract also have a good preventive effect on recurrent cystitis. In an earlier 1993 study of 57 women with recurrent urinary tract infections (at least three infections in a year), patients were treated with bearberry leaf plus dandelion or placebo for a month before the study began After a one-year follow-up, five patients in the placebo group relapsed, but none in the bearberry and dandelion groups. It is reported in the British Medical Journal (BMJ) in 2018 that scholars from the University of Southampton studied the results of combined use of arbutin and ibuprofen as an alternative therapy for urinary tract infections. Combination therapy can reduce antibiotic usage by more than 50% compared to placebo.

The control group that used arbutin reduced the course of antibiotic treatment by 63.6%. A Germany research shows the side effect of arbutin used for UTI treatment. Arbutin caused 8 cases of pyelonephritis and 3 cases of fever while only 3 cases of pyelonephritis and 0 cases of fever in the antibiotic group. At present, arbutin leaves need to be used at a relatively safe dose, of which the daily dose of arbutin is below 840 mg. The long-term safety has not yet been determined. Due to the risk of damage to the liver and kidneys, one-time use is recommended. Do not look more than 1-2 weeks.

Most of the cranberry extract research shows that it still has a certain maintenance effect on women's urinary health. For example, the British Urinary Tract Infection Treatment Recommendations Manual also mentions the role of cranberry, as well as D mannose. But for the role of gynecology and other aspects, the argument is a bit wild. Cranberries are rich in a variety of chemical components: D-mannose (0.1% content), hippuric acid and anthocyanins (the main components). These compounds can limit the ability of infectious bacteria to adhere to the urinary tract, thereby hindering their growth and ability to cause urinary tract infections.

3) Cranberry


Mechanistically, cranberry is an ingredient that is suitable for long-term health care. It is recommended to take it after the urinary tract symptoms have completely disappeared. It seems cranberry extract is a preventative option than a cure for an active UTI.

Cranberry supplementation is also relatively more affordable relatively safe for most people. Please mind the side effect like stomach upset, increase the risk of kidney stones after long-term use. At the same time, the calories in cranberries may lead to unnecessary weight gain and can compromise blood clotting drugs function.

Beside the three ingredients, there are actually many ingredients commonly used for antibacterial and anti-inflammatory, such as berberine, curcumin, marshmallow root, fucus, celery seeds, etc., many of which are compound ingredients.