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Ashwagandha benefits and double blind test

Sep 18, 2021

The history of Ashwagandha can be traced back to about 6000 years ago in Ayurvedic treatment. It is a reputed tonic, also called "Indian ginseng", which can help to keep youthful mind and body. Many of its health benefits are attributed to its high concentration of solanide (withanolide) , as well as other active ingredients such as choline, sitosterol, morlanine, lactine and other alkaloids, scopolamine, Chlorogenic acid, tannins and flavonoids. Throughout the ages, it has been used to:

Ashwagandha root powder

*Reduce inflammation, relieve pain, relieve symptoms of depression and

*Relieve stress

Helps regulate the balance of several hormones (including cortisol) and neurotransmitters

involved in stress response.

*Promote sleep

Somnifera in the Latin botanical name of Ashwagandha, meaning "to induce sleep"

Improve brain function, including memory, promote mental clarity and concentration


In the past 50 years, more than 900 scientific articles on Ashwagandha have been published, including chemical analysis of its components, case history, and research on its effects on cell culture, animals and humans.

In laboratory studies, Ashwagandha can calm the central nervous system, reduce inflammation, and kill cancer cells (but its anti-cancer effect has not been confirmed in human trials).

One of the patented extracts of Ashwagandha with the most in-depth research on the market is: KSM-66 (concentrated from the root of Ashwagandha)

Health-Benefits-Of-Ashwagandha

Research on KSM-66 to relieve stress

In a double-blind placebo-controlled study[1], 300 mg of KSM-66 or placebo was given to 60 people with poor sleep quality twice a day for 10 weeks. (Experimental group (n = 40) and placebo group (n = 20), the random ratio is 2:1)

The results show that KSM-66 Ashwagandha optimizes sleep quality, and the data is very statistically significant. According to the Pittsburgh Sleep Quality Index (PSQI) assessment, the time required to fall asleep and the number of waking up in the middle of the night have been reduced, and overall sleep quality has also been optimized. In the group taking KSM-66, the PSQI was gradually optimized within a month, and the overall optimization was 69%, while the optimization in the placebo group was 11%.

PSQI is a self-answered questionnaire that estimates the seven components of sleep quality (that is, subjective sleep quality, time required to fall asleep, sleep time, number of midnight awakenings, sleep disorders, use of sleep support drugs, and one month Daytime fatigue) to measure sleep quality and patterns.


In another double-blind study [2], 300 mg of KSM-66 or placebo was given to 64 subjects with severe chronic stress twice a day for 60 days. At the end of the study, the scores of the group taking KSM-66 on all stress assessment scales were significantly reduced (P<0.0001), and their serum cortisol levels significantly decreased.


A significant drop in serum cortisol levels.

A double-blind study of adults with some signs of aging [3] evaluated the effectiveness of KSM-66 in optimizing the memory and cognitive functions of these people. 300 mg of KSM-66 or placebo was given to 50 subjects twice a day. After 8 weeks, some widely accepted tests were used to measure memory and cognitive function. According to the subtest scores of logical memory, verbal memory, face and family pictures, the immediate memory and general memory of the KSM-66 group were improved. . Compared with the placebo group, the executive function, sustained attention and information processing speed of the Ashwagandha group were significantly improved. These tests reflect the influence of Ashwagandha on thinking ability (cognitive function).


Research on KSM-66 Improving Cognitive Ability

A double-blind study of adults with some signs of aging [3] evaluated the effectiveness of KSM-66 in optimizing the memory and cognitive functions of these people. 300 mg of KSM-66 or placebo was given to 50 subjects twice a day. After 8 weeks, some widely accepted tests were used to measure memory and cognitive function. According to the subtest scores of logical memory, verbal memory, face and family pictures, the immediate memory and general memory of the KSM-66 group were improved. Compared with the placebo group, the executive function, sustained attention and information processing speed of the Ashwagandha group were significantly improved. These tests reflect the postive influence of Ashwagandha on thinking ability cognitive function.


[1]. ^A Standardized Withania Somnifera Extract Significantly Reduces Stress-Related Parameters in Chronically Stressed Humans: A Double-Blind, Randomized, Placebo-Controlled Study http://www.nuvocare.us/assets/pdf/SleepOn_Cortisol%20Study.pdf

[2]. ^Chengappa K N R , Bowie C R , Schlicht P J , et al. Randomized Placebo-Controlled Adjunctive Study of an Extract of Withania somnifera for Cognitive Dysfunction in Bipolar Disorder[J]. The Journal of Clinical Psychiatry, 2013, 74(11):1076-1083. http://pdfs.semanticscholar.org/0816/1cf1564b6c2658f6d437a441f1eff264cb70.pdf

[3]. ^Pingali, Usharani, Pilli, et al. Effect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participants.[J]. Pharmacognosy Research, 2014.